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A clinical-stage biopharmaceutical company focused on developing oncology therapeutics.

Arno Therapeutics announces dosing of first patient in Phase II clinical research of AR-67 Arno Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing oncology therapeutics, today announced the dosing of the first patient in a Stage II clinical study of its third-generation camptothecin substance, AR-67, in individuals with Glioblastoma Multiforme , an aggressive type of brain cancer signs of infection here . The Phase II, open-label research in up to 56 sufferers is designed to measure the efficacy of AR-67 dosed intravenously for five times on a 21-day cycle before onset of toxicity needing discontinuation or tumor progression, and will include two-cohorts. The scholarly study has been carried out as a multi-centered research led by Duke University, a leading center in the treating brain cancer. The principal objective of the Phase II study is to evaluate the progression free survival of sufferers with GBM treated with AR-67. Secondary endpoints include response rate, and overall survival price. James Vrendenberg, M.D., the main investigator and Medical Director, Adult Clinical Services, Professor of Medication at The Preston Robert Tisch Brain Tumor Center at Duke University. Davis Forsyth Regional Cancer Center .D., the principal investigator at Director and FRCC of Stereotactic Radiation Oncology at FRCC, the only nonacademic, community based clinic participating in the GBM trial.D., shown data on the Stage 1 clinical research of ARC-520, the organization's clinical applicant for the treatment of chronic hepatitis B disease, at the HepDART 2013 conference being held on The Big Island, Hawaii. New data including pharmacokinetics and adverse event attribution provided today in a poster and in an oral display tomorrow, support the previous findings that ARC-520 appears to be safe and well-tolerated at all six dose amounts studied generally. The Phase 1 research was designed to characterize the security profile of ARC-520 across a variety of doses and assess pharmacokinetics. It is a single-middle, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human research of ARC-520 administered intravenously to healthy adult volunteers.01 mg/kg , 0.1 mg/kg , 0.3 mg/kg , 0.6 mg/kg , 1.2 mg/kg , and 2.0 mg/kg . The placebo group included 7 male and 5 female subjects with average of 28.1 +/ – 9.6 years. The treatment group included 12 male and 12 female topics with average age group of 26.9 +/ – 6.7 years. Subjects were admitted to the unit overnight pre-dose and vital signs, telemetry, ECGs, safety labs, PK, and adverse events were monitored for 24 hours post-dose. Return visits occurred for repeat basic safety evaluations and recording of adverse events at 48 hrs, 72 hours, day 7, day 14 and day 28 post dosing. Related StoriesLenvatinib trial presents hope for thyroid tumor patientsLiposomal sizing and the Coulter principle: an interview with Professor Melvin E. KlegermanExpanded make use of for IntelliCap with further CE Tag for aspiration of fluids Preliminary outcomes from the phase 1 clinical study of ARC-520 indicate that to date there have been no critical AEs, no dosage limiting toxicities, no discontinuations, and a modest occurrence rate of AEs without dose related increase in frequency or severity, with the possible exception of moderate lightheadedness which happened in two subjects in the 2 2 mg/kg dosage group. There were no general differences observed or findings ranked clinically significant on vital signs, ECGs, physical examinations, or medical laboratories in the ARC-520 groups in accordance with placebo. Adverse event intensity and frequency didn’t differ between placebo and ARC-520, with 75 percent of both treated and placebo subjects reporting gentle or moderate AEs. There is a low occurrence rate of abnormal laboratory tests, with no observed romantic relationship to timing or dose.984). The Phase 1 research has thus demonstrated a solitary intravenous administration of ARC-520 appears to be secure and well tolerated up to and including a dosage of 2 mg/kg, the best dose tested. . Continue reading

Can marijuana heal a wounded warrior?

He and various other volunteers lately spent a day putting together bags of marijuana items that are given away on holidays, like Memorial Day. CBS Evening Information VA PTSD treatment inadequate, study shows Two recent studies confirm widespread veteran concern with VA mental healthcare. One challenge is that both Pentagon and the VA have got attacke. The marijuana is intended to take care of war wounds – – both the mental and the physical kind that doctors often treat with medications like oxycontin. Based on the VA, 20 % of veterans returning from Afghanistan and Iraq suffer from post-traumatic stress. Continue reading

Causes of type 1 diabetes Researchers are casting a wide.

She. That’s why TEDDY – ENVIRONMENTALLY FRIENDLY Determinants of Diabetes in the Adolescent – was born. The scholarly study includes newborns in four states and three countries. MCG is the lead site for seven hospitals, including MCG Medical Center, University St and Hospital. Joseph Medical center in Augusta; Northside Hospital in Atlanta; and three hospitals in Gainesville, Fla. Additional lead sites include Barbara Davis Center at the University of Colorado; Pacific Northwest Research Institute in Seattle; the University of Turku in Finland; Lund University in Sweden; and the Diabetes Study Institute in Munich, Germany. Continue reading

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Andrew Wakefield conducted operations on children including colonoscopies and lumbar punctures that have been arguably unnecessary and demonstrated ‘callous disregard for the distress and pain’ the kids might suffer as a result of his actions. The amount of money was paid into a merchant account held by trustees at the Royal Free for the purposes of Dr. Wakefield’s research, so that five kids and their families could stay static in hospital during checks and for MRI scans for every child. However those costs could have been fulfilled by the NHS and Wakefield provides been accused of using the amount of money ‘for purposes apart from those for which he said it was needed’, that was both ‘dishonest’ and ‘misleading’. Related StoriesGenetic carrier screening: an interview with Don Hardison, CEO of Good Start GeneticsAmputation isn’t wound healingNew scientific chemistry analyzer launched by EKF at Medica 2015The study triggered a furore and led to falling amounts of parents immunising their kids and in addition initiated a row over if the then primary minister Tony Blair experienced vaccinated his young boy. Continue reading

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As defunding vote triggers GOP family feud.

But provided Democratic control of the Senate and White colored House -; and developing Republican reticence about shutting down the national authorities -; even Cruz's GOP supporters acknowledge there's without any chance his tactics will succeed . Related StoriesRE. Rand Paul on Thursday defended Defund Obamacare supporters in the Senate, who have come under criticism from Home Republicans for suggesting they may not have the ability to stop a budget that includes financing for Obamacare. Paul observed that actually his 13-hour filibuster against the Obama administration's drone plans wasn't in a position to quit the Senate from approving the nomination of CIA director John Brennan . Continue reading

California Chapter will keep its annual Breath of Lifestyle Ball on Tuesday.

With a silent auction and superstar reception accompanied by dinner, plan, entertainment and a live auction starting at 7:30 p.m. Related StoriesUtah experts awarded NIH grant to develop informatics platform to recognize cause of pediatric asthmaMayo Clinic research analyzes asthma outcomes after individuals stage down daily medicinesDifferent types of asthma react differently to fresh experimental treatmentDonald T. Sterling, Owner of the LA Clippers will receive the Man of the entire year Award; John Fiedler, President of Southern California Edison shall be bestowed environmentally friendly Leadership Award; Dr. Continue reading